A meta-analysis of randomized trials of calcium antagonists to reduce restenosis after coronary angioplasty

Academic Article

Abstract

  • The usefulness of calcium antagonists to reduce restenosis after coronary angioplasty remains uncertain despite 5 randomized trials involving 919 patients. Review and meta-analysis of these trials are performed to provide insight into whether calcium antagonists reduce anglographic restenosis. In aggregate, these trials suggest that patients treated with calcium antagonists had approximately a 30% reduction in the odds of angiographic restenosis (odds ratio = 0.68; 95% confidence interval of 0.49 to 0.94, p = 0.03) compared with control patients. Given the relatively low toxicity and cost of these agents, this reduction In angiographic restenosis may translate Into a meaningful clinical benefit. A large, randomized clinical trial should be performed to confirm these findings before widespread adoption of this treatment strategy. © 1994.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Hillegass WB; Ohman EM; Leimberger JD; Califf RM
  • Start Page

  • 835
  • End Page

  • 839
  • Volume

  • 73
  • Issue

  • 12