The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival

Academic Article

Abstract

  • Apolipoprotein L-1 (APOL1) gene variants are associated with end-stage renal disease in African Americans (AAs). Here we investigate the impact of recipient APOL1 gene distributions on kidney allograft outcomes. We conducted a retrospective analysis of 119 AA kidney transplant recipients, and found that 58 (48.7%) carried two APOL1 kidney disease risk variants. Contrary to the association seen in native kidney disease, there is no difference in allograft survival at 5-year posttransplant for recipients with high-risk APOL1 genotypes. Thus, we were able to conclude that APOL1 genotypes do not increase risk of allograft loss after kidney transplantations, and carrying 2 APOL1 risk alleles should not be an impediment to transplantation. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.
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    Digital Object Identifier (doi)

    Author List

  • Lee BT; Kumar V; Williams TA; Abdi R; Bernhardy A; Dyer C; Conte S; Genovese G; Ross MD; Friedman DJ
  • Start Page

  • 1924
  • End Page

  • 1928
  • Volume

  • 12
  • Issue

  • 7