Abatacept in B7-1-positive proteinuric kidney disease

Academic Article

Abstract

  • Abatacept (cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion protein [CTLA-4-Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who had focal segmental glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and one with primary FSGS) and proteinuria with B7-1 immunostaining of podocytes in kidney-biopsy specimens. Abatacept induced partial or complete remissions of proteinuria in these patients, suggesting that B7-1 may be a useful biomarker for the treatment of some glomerulopathies. Our data indicate that abatacept may stabilize β1-integrin activation in podocytes and reduce proteinuria in patients with B7-1-positive glomerular disease. Copyright © 2013 Massachusetts Medical Society.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Yu CC; Fornoni A; Weins A; Hakroush S; Maiguel D; Sageshima J; Chen L; Ciancio G; Faridi MH; Behr D
  • Start Page

  • 2416
  • End Page

  • 2423
  • Volume

  • 369
  • Issue

  • 25