31P NMR spectroscopy of in vivo tumors

Academic Article

Abstract

  • A probe, suitable for any wide-bore NMR spectrometer, was constructed for monitoring high-resolution spectra of in vivo subcutaneously implanted tumors in mice. Preliminary studies of a variety of murine tumors (MOPC 104E myeloma, Dunn osteosarcoma, colon-26, ovarian M5, and mammary adenocarcinoma as well as human colon, mammary, and lung tumors in athymic mice) indicate that the 31P NMR spectrum is a sensitive monitor of progressive metabolic changes that occur during untreated tumor growth and an early indicator of tumor response to chemotherapy, hyperthermia, and X radiation. Response to each of these therapeutic modalities is accompanied by distinctly different spectral changes. © 1982.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ng TC; Evanochko WT; Hiramoto RN; Ghanta VK; Lilly MB; Lawson AJ; Corbett TH; Durant JR; Glickson JD
  • Start Page

  • 271
  • End Page

  • 286
  • Volume

  • 49
  • Issue

  • 2