The therapeutic potential of CFTR modulators for COPD and other airway diseases.

Academic Article

Abstract

  • Airways diseases, especially chronic obstructive pulmonary disease (COPD) and asthma, are common causes of morbidity and mortality worldwide. There is an ongoing unmet need for novel and effective therapies. There is an established pathophysiological link and phenotypic similarity between the chronic bronchitis phenotype of COPD and cystic fibrosis (CF). New evidence suggests that CFTR dysfunction may play a role in other common airways diseases such as COPD, non-atopic asthma and non-CF bronchiectasis. Newly approved and investigational drugs that target both mutant and wild-type CFTR channels have provided a new treatment opportunity addressing the mucus defect in pulmonary diseases that share the same pathophysiology with CF.
  • Published In

    Keywords

  • Animals, Cystic Fibrosis Transmembrane Conductance Regulator, Humans, Lung Diseases, Phosphodiesterase 4 Inhibitors, Smoking
  • Digital Object Identifier (doi)

    Authorlist

  • Solomon GM; Fu L; Rowe SM; Collawn JF
  • Start Page

  • 132
  • End Page

  • 139
  • Volume

  • 34