Advances in chemotherapeutic agents, targeted radiation therapy, and surgical procedures have made cancer care increasingly complex. In addition, cancer patients and their families have become more sophisticated and demanding in the delivery of quality healthcare. An oncology multidisciplinary clinic (MDC) can address these trends, raising the standard of care and improving the experience of patients during a difficult time. As a coordinated patient consultation, an MDC provides definitive diagnosis and treatment planning based on the input of an assortment of medical specialists and support services. In this article, the authors discuss their personal experience developing MDCs at the Christiana Care Helen F. Graham Cancer Center in Newark, DE. © 2006 Elsevier Inc. All rights reserved.