TβRIII is induced by TCR signaling and downregulated in FoxP3+ regulatory T cells

Academic Article

Abstract

  • © 2017 TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different checkpoints during T cell differentiation. We have previously reported that TβRIII modulates T cell development by protecting developing thymocytes from apoptosis, however the role of this co-receptor in peripheral lymphocytes still remains elusive. Here we describe a detailed characterization of TβRIII expression in murine and human lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naïve and central memory T cells. TβRIII was upregulated after TCR stimulation, in parallel to other early activation markers. In contrast, natural and induced Tregs downregulated TβRIII in association with FoxP3 upregulation. Finally, anti-TβRIII blocking experiments demonstrated that TβRIII promotes TGFβ-dependent iTreg conversion in vitro, and suggest that this co-receptor may be involved in modulating peripheral T cell tolerance and could be considered as a potential target to boost T cell immune responses.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Ortega-Francisco S; de la Fuente-Granada M; Alvarez Salazar EK; Bolaños-Castro LA; Fonseca-Camarillo G; Olguin-Alor R; Alemán-Muench GR; López-Casillas F; Raman C; García-Zepeda EA
  • Start Page

  • 82
  • End Page

  • 87
  • Volume

  • 494
  • Issue

  • 1-2