Parametric modeling of localized melanoma prognosis and outcome.

Academic Article


  • This investigation explored the most suitable parametric model for melanoma prognosis and compared it with the Cox model. Cox-Snell residuals and survival function plots were applied to assess whether the generalized gamma (GG) model was the best-fit parametric model for the data. The GG model is a powerful alternative to the Cox model in prognostic modeling. The GG model offers an advantage of explicit and flexible individualized hazard functions over the Cox model and provides a clinically useful risk assessment over time to aid clinicians in formulating patient treatment, follow-up plans, and clinical trial design and analysis.
  • Keywords

  • Age Factors, Chi-Square Distribution, Data Interpretation, Statistical, Databases as Topic, Female, Humans, Kaplan-Meier Estimate, Likelihood Functions, Male, Melanoma, Middle Aged, Models, Statistical, Neoplasm Staging, Proportional Hazards Models, Risk Assessment, Risk Factors, Sex Factors, Survival Analysis, Time Factors, Treatment Outcome
  • Digital Object Identifier (doi)

    Author List

  • Ding S; Soong S-J; Lin H-Y; Desmond R; Balch CM
  • Start Page

  • 732
  • End Page

  • 747
  • Volume

  • 19
  • Issue

  • 4