Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kit+ Cells

Academic Article

Abstract

  • BACKGROUND: Although cardiac c-kit+ cells are being tested in clinical trials, the circumstances that determine lineage differentiation of c-kit+ cells in vivo are unknown. Recent findings suggest that endogenous cardiac c-kit+ cells rarely contribute cardiomyocytes to the adult heart. We assessed whether various pathological stimuli differentially affect the eventual cell fates of c-kit+ cells.
  • Authors

    Published In

  • Circulation  Journal
  • Digital Object Identifier (doi)

    Author List

  • Chen Z; Zhu W; Bender I; Gong W; Kwak IY; Yellamilli A; Hodges TJ; Nemoto N; Zhang J; Garry DJ
  • Start Page

  • 2359
  • End Page

  • 2372
  • Volume

  • 136
  • Issue

  • 24