Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study.

Academic Article


  • OBJECTIVE: To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. METHODS: Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. RESULTS: At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. CONCLUSIONS: Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.
  • Published In

  • Obesity Research  Journal
  • Keywords

  • Absorptiometry, Photon, Aged, Behavior Therapy, Body Composition, Caloric Restriction, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Follow-Up Studies, Humans, Life Style, Male, Middle Aged, Obesity, Overweight, Patient Education as Topic, Weight Loss, Weight Reduction Programs
  • Digital Object Identifier (doi)

    Author List

  • Pownall HJ; Bray GA; Wagenknecht LE; Walkup MP; Heshka S; Hubbard VS; Hill J; Kahn SE; Nathan DM; Schwartz AV
  • Start Page

  • 565
  • End Page

  • 572
  • Volume

  • 23
  • Issue

  • 3