Structure and specificity of a class II MHC alloreactive γδ T cell receptor heterodimer

Academic Article

Abstract

  • Two distinct CD3-associated T cell receptors (TCRαβ and TCRγδ) are expressed in a mutually exclusive fashion on separate subsets of T lymphocytes. While the specificity of the TCRαβ repertoire for major histocompatibility complex (MHC) antigens is well established, the diversity of expressed γδ receptors and the ligands they recognize are less well understood. An alloreactive CD3+CD4-CD8-T cell line specific for murine class II MHC (Ia) antigens encoded in the I-E subregion of the H-2 gene complex was identified, and the primary structure of its γδ receptor heterodimer was characterized. In contrast to a TCRαβ-expressing alloreactive T cell line selected for similar specificity, the TCRγδ line displayed broad cross-reactivity for multiple distinct I-E-encoded allogeneic Ia molecules.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Matis LA; Fry AM; Cron RQ; Cotterman MM; Dick RF; Bluestone JA
  • Start Page

  • 746
  • End Page

  • 749
  • Volume

  • 245
  • Issue

  • 4919