Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.

Academic Article

Abstract

  • 2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.
  • Published In

    Keywords

  • Animals, Antineoplastic Agents, Antiviral Agents, Carcinoma, Squamous Cell, Chemical Phenomena, Chemistry, Cytomegalovirus, Deoxycytidine, Deoxyuridine, Humans, Leukemia L1210, Leukemia, T-Cell, Mice, Simplexvirus, Thionucleosides, Thiouridine, Thymidine, Tumor Cells, Cultured
  • Pubmed Id

  • 17130839
  • Authorlist

  • Secrist JA; Tiwari KN; Riordan JM; Montgomery JA
  • Start Page

  • 2361
  • End Page

  • 2366
  • Volume

  • 34
  • Issue

  • 8