Synthesis and Biological Activity of 2′-Deoxy-4′-thio Pyrimidine Nucleosides

Academic Article

Abstract

  • 2′-Deoxy-4′-thiocytidine (7β), 2′-deoxy-4′-thiouridine (9), and 4′-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4′-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture. © 1991, American Chemical Society. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 17130839
  • Author List

  • Secrist JA; Tiwari KN; Riordan JM; Montgomery JA
  • Start Page

  • 2361
  • End Page

  • 2366
  • Volume

  • 34
  • Issue

  • 8