Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides.

Academic Article

Abstract

  • A series of 2',3'-dideoxy-4'-thionucleoside analogues of purines and pyrimidines, including 4'-thioddI (17), 4'-thioddC (27), and 4'-thioAZT (34), were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV). A stereospecific synthesis of the 2,3-dideoxy-4-thioribofuranosyl carbohydrate precursor 11 starting with L-glutamic acid is described. 2',3'-Dideoxy-4'-thiocytidine (27) displayed significant, but modest activity in vitro against human immunodeficiency virus.
  • Published In

    Keywords

  • Antiviral Agents, Dideoxynucleosides, HIV
  • Author List

  • Secrist JA; Riggs RM; Tiwari KN; Montgomery JA
  • Start Page

  • 533
  • End Page

  • 538
  • Volume

  • 35
  • Issue

  • 3