Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 2. 9-Alicyclic and 9-Heteroalicyclic Derivatives of 9-Deazaguanine

Academic Article


  • Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5-dihydro-4H-pyrrolo[3,2-d] [pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside Phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivatives previously investigated. The mode of binding of these compounds to PNP was determined by X-ray crystallography. © 1993, American Chemical Society. All rights reserved.
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    Author List

  • Secrist JA; Niwas S; Rose JD; Babu YS; Bugg CE; Erion MD; Guida WC; Ealick SE; Montgomery JA
  • Start Page

  • 1847
  • End Page

  • 1854
  • Volume

  • 36
  • Issue

  • 13