Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine.

Academic Article

Abstract

  • Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5-dihydro-4H-pyrrolo[3,2-d] [pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivatives previously investigated. The mode of binding of these compounds to PNP was determined by X-ray crystallography.
  • Published In

    Keywords

  • Binding Sites, Cycloparaffins, Drug Design, Guanine, Models, Molecular, Molecular Conformation, Monte Carlo Method, Protein Binding, Purine-Nucleoside Phosphorylase, Structure-Activity Relationship, Thermodynamics, X-Ray Diffraction
  • Author List

  • Secrist JA; Niwas S; Rose JD; Babu YS; Bugg CE; Erion MD; Guida WC; Ealick SE; Montgomery JA
  • Start Page

  • 1847
  • End Page

  • 1854
  • Volume

  • 36
  • Issue

  • 13