Syntheses of 5'-substituted analogues of carbocyclic 3-deazaadenosine as potential antivirals.

Academic Article

Abstract

  • Various 5'-substituted derivatives (2, 3, 6a, 6b, 9a, 9b, 12, 13b, and 15) of carbocyclic 3-deazaadenosine (3-deaza CAdo, 1) were prepared from 3-deaza CAdo (1) and evaluated as antiviral agents against a number of viruses, including HIV-1. Several of the compounds had moderate to good antiviral activity against vaccinia (VV) and vesicular stomatitis (VSV) viruses; however, the antiviral activity of the analogues did not exceed that of the parent compound. No anti-HIV activity was detected.
  • Published In

    Keywords

  • Antiviral Agents, Microbial Sensitivity Tests, Structure-Activity Relationship, Tubercidin
  • Pubmed Id

  • 18603266
  • Authorlist

  • Secrist JA; Comber RN; Gray RJ; Gilroy RB; Montgomery JA
  • Start Page

  • 2102
  • End Page

  • 2106
  • Volume

  • 36
  • Issue

  • 15