Synthesis and biological activity of 4'-thio-2'-deoxy purine nucleosides.

Academic Article


  • Coupling of 1-O-acetyl-2-deoxy-3,5-di-O-toluoyl-4-thio-D-ribofuranose with 6-chloropurine and 2,6-dichloropurine gave a mixture of 9 alpha and 9 beta anomers as major products. These anomers were separated and converted to 2'-deoxy-4'-thio analogues of adenosine, inosine, guanosine, 2-amino-adenosine, and 2-chloro adenosine as well as their alpha-anomers.
  • Published In


  • Animals, Cell Division, Cell Line, Cell Survival, Humans, Mice, Purine Nucleosides
  • Author List

  • Messini L; Tiwari KN; Montgomery JA; Secrist JA
  • Start Page

  • 683
  • End Page

  • 685
  • Volume

  • 18
  • Issue

  • 4-5