Convenient syntheses of 6-methylpurine and related nucleosides.

Academic Article

Abstract

  • Efficient methods for the synthesis of 6-methylpurine (3), 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methylpurine (8), and 6-methyl-9-beta-D-ribofuranosylpurine (5) are described. Methodology involving the (Ph3P)4Pd catalyzed cross-coupling reaction of CH3ZnBr with several different 6-chloropurine derivatives is described in high yield. This methodology now provides a facile and high-yielding synthesis of 8, which is needed in significant amounts for studies in cancer gene therapy.
  • Published In

    Keywords

  • Antineoplastic Agents, Bromides, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Magnetic Resonance Spectroscopy, Monosaccharides, Nucleosides, Purine Nucleosides, Purines, Zinc Compounds
  • Digital Object Identifier (doi)

    Authorlist

  • Hassan AE; Abou-Elkair RA; Montgomery JA; Secrist JA
  • Start Page

  • 1123
  • End Page

  • 1134
  • Volume

  • 19
  • Issue

  • 7