Synthesis and antiproliferative activity of some 4'-C-hydroxymethyl-alpha- and -beta-D-arabino-pentofuranosyl pyrimidine nucleosides.

Academic Article

Abstract

  • A suitably protected 4-C-hydroxymethyl-arabino-pentofuranose was prepared and condensed with the following nucleobases: uracil, 5-fluorouracil and thymine. The corresponding cytosine and 5-fluorocytosine derivatives have also been obtained respectively from the uracil and 5-fluorouracil nucleosides. Separation of the anomeric mixtures followed by deprotection afforded the target compounds that were found to be non-cytotoxic to CCRF-CEM leukemia cells.
  • Published In

    Keywords

  • Antineoplastic Agents, Fluorouracil, Humans, Leukemia, Pentoses, Pyrimidine Nucleosides, Thymine, Tumor Cells, Cultured, Uracil
  • Digital Object Identifier (doi)

    Author List

  • Griffon JF; Montgomery JA; Secrist JA
  • Start Page

  • 649
  • End Page

  • 652
  • Volume

  • 20
  • Issue

  • 4-7