Synthesis and biological activity of 4'-thio-L-xylofuranosyl nucleosides.

Academic Article

Abstract

  • A series of 4'-thio-L-xylofuranosyl nucleosides were prepared and evaluated as potential anticancer and antiviral agents. The details of a convenient and high-yielding synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O-benzyl-4-thio-L-xylofuranose (6) are presented. Proof of structure and configuration at all chiral centers of the nucleosides was obtained by proton and carbon NMR. All target compounds were evaluated in a series of human cancer cell lines in culture and as antiviral agents.
  • Published In

    Keywords

  • Antineoplastic Agents, Antiviral Agents, Carbohydrate Conformation, Drug Screening Assays, Antitumor, Humans, Microbial Sensitivity Tests, Nuclear Magnetic Resonance, Biomolecular, Stereoisomerism, Thionucleosides, Xylose
  • Digital Object Identifier (doi)

    Authorlist

  • Tiwari KN; Messini L; Montgomery JA; Secrist JA
  • Start Page

  • 743
  • End Page

  • 746
  • Volume

  • 20
  • Issue

  • 4-7