Synthesis and biological activity of 4'-C-hydroxymethyl-2'-fluoro-D-arabinofuranosylpurine nucleosides.

Academic Article

Abstract

  • A series of 4'-C-hydroxymethyl-2'-fluoro-D-arabinofuranosylpurine nucleosides was prepared and evaluated for cytotoxicity in human tumor cell lines. A convenient synthesis of the carbohydrate precursor 4-C-hydroxymethyl-3,5-di-O-benzoyl-2-fluoro-alpha-D-arabinofuranosyl bromide (13) was developed. Coupling of 13 with the sodium salt of 2,6-dichloropurine led to five target purine nucleosides.
  • Published In

    Keywords

  • Antineoplastic Agents, Arabinonucleosides, Drug Screening Assays, Antitumor, Humans, Purine Nucleosides, Tumor Cells, Cultured
  • Digital Object Identifier (doi)

    Pubmed Id

  • 18096474
  • Authorlist

  • Shortnacy-Fowler AT; Tiwari KN; Montgomery JA; Secrist JA
  • Start Page

  • 747
  • End Page

  • 750
  • Volume

  • 20
  • Issue

  • 4-7