Synthesis of some 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D-lyxofuranosyl nucleosides

Academic Article

Abstract

  • 1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)uracil (5) and 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine (6) were synthesized as reported earlier. Both of these compounds were converted into 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D- lyxofuranosyl nucleosides (16-19) by a multistep sequence. All these new nucleosides were evaluated against seven human tumor cell lines in vitro. Copyright © Taylor & Francis, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Moukha-Chafiq O; Tiwari KN; Secrist JA
  • Start Page

  • 713
  • End Page

  • 715
  • Volume

  • 24
  • Issue

  • 5-7