Synthesis of some 2'-fluoro-2'-deoxy-3'-C-ethynyl and 3'-C-vinyl-beta-D-lyxofuranosyl nucleosides.

Academic Article


  • 1-(2-Fluoro-2-deoxy-beta-D-drabinofuranosyl) uracil (5) and 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)cytosine (6) were synthesized as reported earlier. Both of these compounds were converted into 2'-fluoro-2'-deoxy-3'-C-ethynyl and 3'-C-vinyl-beta-D-lyxofuranosyl nuclearsides (16-19) by a multistep sequence. All these new nucleosides were evaluated against seven human tumor cell lines in vitro.
  • Published In


  • Arabinonucleotides, Cell Line, Tumor, Chemistry, Pharmaceutical, Cytosine, Drug Design, Drug Screening Assays, Antitumor, Humans, In Vitro Techniques, Magnetic Resonance Spectroscopy, Models, Chemical, Pyrimidine Nucleosides
  • Author List

  • Moukha-chafiq O; Tiwari KN; Secrist JA
  • Start Page

  • 713
  • End Page

  • 715
  • Volume

  • 24
  • Issue

  • 5-7