(S)- N -(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2- carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection

Academic Article

Abstract

  • A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a sulfonylpyrrolidine scaffold resulted in compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC50 = 2.3 ± 0.8 μM) with marginal cytotoxicity (CC50 = 30.9 ± 1.1 μM) and reduced viral titer by 100-fold. Compared to ribavirin, sulfonylpyrrolidine 5o demonstrated an improved in vitro potency and selectivity index. © 2012 American Chemical Society.
  • Digital Object Identifier (doi)

    Author List

  • Moore BP; Chung DH; Matharu DS; Golden JE; Maddox C; Rasmussen L; Noah JW; Sosa MI; Ananthan S; Tower NA
  • Start Page

  • 8582
  • End Page

  • 8587
  • Volume

  • 55
  • Issue

  • 20