Synthesis of 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid: A selective carnitine palmitoyltransferase-1 inhibitor

Academic Article

Abstract

  • Carnitine palmitoyltransferases 1 and 2 (CPT-1 and CPT-2) catalyze the transfer of long chain fatty acids between carnitine and coenzyme A. Unlike CPT-2, CPT-1 exists in at least two isoforms with different physical and kinetic properties. Liver and skeletal muscle each contain a different isoform of CPT-1. Cardiac muscle contains both isoforms, and the minor component is identical to the isoform found in the liver. 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid (2) was reported to be a selective inhibitor for the liver isoform of CPT-1. A synthesis of 2 is described here which involves the reaction of diethyl malonate with 1-bromo-6-phenoxyhexane. Copyright (C) 1997 Elsevier Science Ltd.
  • Digital Object Identifier (doi)

    Author List

  • Hutchison TL; Brouillette WJ
  • Start Page

  • 2133
  • End Page

  • 2138
  • Volume

  • 6
  • Issue

  • 11