Optimizing Cholesterol Treatment in Patients With Muscle Complaints.

Academic Article


  • Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction amongĀ individuals reporting statin-associated muscle symptoms.
  • Authors


  • cardiovascular disease, low-density lipoprotein, myalgia, myopathy, statin intolerance, Anticholesteremic Agents, Cardiovascular Diseases, Cholesterol, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscle, Skeletal, Muscular Diseases, Risk Factors
  • Digital Object Identifier (doi)

    Author List

  • Rosenson RS; Baker S; Banach M; Borow KM; Braun LT; Bruckert E; Brunham LR; Catapano AL; Elam MB; Mancini GBJ
  • Start Page

  • 1290
  • End Page

  • 1301
  • Volume

  • 70
  • Issue

  • 10