Spleen Tyrosine Kinase Confers Paclitaxel Resistance in Ovarian Cancer

Academic Article

Abstract

  • © 2015 Elsevier Inc. Adaptive chemoresistance and consequent tumor recurrence present major obstacles to the improvement of the prognosis and quality-of-life of patients with advanced-stage ovarian cancer. In this issue of Cancer Cell, Yu and colleagues describe the critical role of spleen tyrosine kinase (SYK) in paclitaxel resistance by modulating the stability of microtubules. Adaptive chemoresistance and consequent tumor recurrence present major obstacles to the improvement of the prognosis and quality-of-life of patients with advanced-stage ovarian cancer. In this issue of Cancer Cell, Yu and colleagues describe the critical role of spleen tyrosine kinase (SYK) in paclitaxel resistance by modulating the stability of microtubules.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 18466813
  • Author List

  • Wei W; Birrer MJ
  • Start Page

  • 7
  • End Page

  • 9
  • Volume

  • 28
  • Issue

  • 1