Olfactory exposure to males, including men, causes stress and related analgesia in rodents

Academic Article


  • We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing. © 2014 Nature America, Inc.
  • Authors

    Published In

  • Nature Methods  Journal
  • Digital Object Identifier (doi)

    Author List

  • Sorge RE; Martin LJ; Isbester KA; Sotocinal SG; Rosen S; Tuttle AH; Wieskopf JS; Acland EL; Dokova A; Kadoura B
  • Start Page

  • 629
  • End Page

  • 632
  • Volume

  • 11
  • Issue

  • 6