Effect of treatment with continuous positive airway pressure or oxygen on sleep-disordered breathing in patients with heart failure: results of the Sleep Events, Arrhythmias, and Respiratory Analysis in Chronic Heart Failure (SEARCH) study.

Academic Article


  • The response to sleep-disordered breathing (SDB)-directed therapy was evaluated using the Clear Path home-based monitoring system. There were 26 patients with heart failure enrolled in the Sleep Events, Arrhythmias, and Respiratory Analysis in Chronic Heart Failure (SEARCH) study with SDB requiring treatment (apnea-hypopnea index [AHI] >or=15 events/h). Patients were monitored using both standard polysomnography and the Clear Path system to determine the change in SDB parameters before and after initiation of therapy. Accuracy of the Clear Path system compared with polysomnography was >or=87% to detect SDB events. A marked reduction in the mean number of sleep time respiratory disturbances was observed by both techniques after the initiation of SDB-directed therapy, and 21 patients (87.5%) experienced a 16.7-events/h mean reduction in AHI. Thus, the Clear Path system appears to be a useful device to monitor response to SDB-directed treatment for apnea in patients with heart failure.
  • Authors

    Published In


  • Adult, Aged, Arrhythmias, Cardiac, Continuous Positive Airway Pressure, Female, Heart Failure, Humans, Male, Middle Aged, Oxygen Inhalation Therapy, Polysomnography, Prospective Studies, Respiratory Function Tests, Respiratory System, Sensitivity and Specificity, Sleep Apnea, Central, Time Factors, Treatment Outcome
  • Pubmed Id

  • 23221830
  • Author List

  • Abraham WT; Trupp RJ; Phillips B; Bourge RC; Harding SM; Schofield P; Pilsworth S; Shneerson JM; Di Salvo T; Camuso J
  • Start Page

  • 197
  • End Page

  • 201
  • Volume

  • 14
  • Issue

  • 4