In Vitro Activities of Gepotidacin (GSK2140944) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas.

Academic Article

Abstract

  • Gepotidacin, a novel first-in-class triazaacenaphthylene topoisomerase II inhibitor, was tested against 85 type strains and clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma parvum, and Ureaplasma urealyticum in comparison to levofloxacin, moxifloxacin, azithromycin or clindamycin, and tetracycline. Gepotidacin MIC90s (μg/ml) were 0.125 (M. pneumoniae), 0.032 (M. genitalium), 2 (M. hominis), and 8 (Ureaplasma species). Gepotidacin activity was not affected by resistance to fluoroquinolones, tetracyclines, or macrolides in the strains tested. Gepotidacin merits further study for treating infections caused by these organisms.
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    Keywords

  • antimicrobial resistance, gepotidacin (GSK2140944), mycoplasma, ureaplasma, Acenaphthenes, Anti-Bacterial Agents, Drug Resistance, Bacterial, Fluoroquinolones, Heterocyclic Compounds, 3-Ring, Humans, Macrolides, Microbial Sensitivity Tests, Mycoplasma Infections, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae, Tetracyclines, Topoisomerase II Inhibitors, Ureaplasma, Ureaplasma Infections, Ureaplasma urealyticum
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    Author List

  • Waites KB; Crabb DM; Xiao L; Duffy LB
  • Volume

  • 61
  • Issue

  • 10