Hippocampal IGF-1 expression, neurogenesis and slowed aging: Clues to longevity from mutant mice

Academic Article


  • Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed. © Springer Science + Business Media B.V. 2006.
  • Authors

    Published In

  • AGE  Journal
  • Digital Object Identifier (doi)

    Author List

  • Sun LY
  • Start Page

  • 181
  • End Page

  • 189
  • Volume

  • 28
  • Issue

  • 2