Inhibition of FOXO1/3 promotes vascular calcification

Academic Article

Abstract

  • Objective: Vascular calcification is a characteristic feature of atherosclerosis, diabetes mellitus, and end-stage renal disease. We have demonstrated that activation of protein kinase B (AKT) upregulates runt-related transcription factor 2 (Runx2), a key osteogenic transcription factor that is crucial for calcification of vascular smooth muscle cells (VSMC). Using mice with SMC-specific deletion of phosphatase and tensin homolog (PTEN), a major negative regulator of AKT, the present studies uncovered a novel molecular mechanism underlying PTEN/AKT/FOXO (forkhead box O)-mediated Runx2 upregulation and VSMC calcification.
  • Digital Object Identifier (doi)

    Author List

  • Deng L; Huang L; Sun Y; Heath JM; Wu H; Chen Y
  • Start Page

  • 175
  • End Page

  • 183
  • Volume

  • 35
  • Issue

  • 1