Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration

Academic Article


  • Purpose: To summarize and contextualize recent histology and clinical imaging publications on retinal pigment epithelium (RPE) fate in advanced age-related macular degeneration (AMD); to support RPE activation and migration as important precursors to atrophy, manifest as intraretinal hyperreflective foci in spectral-domain optical coherence tomography (SDOCT).
  • Digital Object Identifier (doi)

    Author List

  • Curcio CA; Zanzottera EC; Ach T; Balaratnasingam C; Freund KB
  • Start Page

  • BIO211
  • End Page

  • BIO226
  • Volume

  • 58
  • Issue

  • 6