Age and Sex Disparities in Discharge Statin Prescribing in the Stroke Belt: Evidence From the Reasons for Geographic and Racial Differences in Stroke Study.

Academic Article


  • BACKGROUND: Stroke is a costly and debilitating disease that disproportionately affects blacks. Despite the efficacy of statins, evidence suggests racial disparities may exist in statin prescribing. METHODS AND RESULTS: We analyzed discharge medications for participants hospitalized for an ischemic stroke during follow-up of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Medications on admission and discharge were abstracted from medical records. Among the 666 eligible incident strokes (2003-2013), analyses were restricted to 323 participants who were not statin users at the time of admission and had no history of atrial fibrillation. Overall, 48.7% were prescribed a statin on discharge. In the Stroke Belt, participants aged 65¬†years and older were 47% less likely to be discharged on a statin compared with those younger than 65 years (relative risk [RR], 0.53; 95% CI, 0.38-0.74). This association was not observed in non-Stroke Belt residents. Outside the Stroke Belt, blacks were more likely than whites to be discharged on a statin (RR, 1.42; 95% CI, 1.04-1.94), while no black:white association was present among Stroke Belt residents (RR, 0.93; 95% CI, 0.69-1.26; P for interaction=0.228). Compared with women, men in the Stroke Belt were 31% less likely to be discharged on a statin (RR, 0.69; 95% CI, 0.50-0.94) while men outside the Stroke Belt were more likely to be discharged on a statin (RR, 1.38; 95% CI, 0.99-1.92; P for interaction=0.004). CONCLUSIONS: Statin discharge prescribing may differ among Stroke Belt and non-Stroke Belt residents, particularly in older Americans and men.
  • Keywords

  • disparities, prescribing patterns, secondary prevention, statins, stroke, African Americans, Age Distribution, Aged, Aged, 80 and over, Atrial Fibrillation, European Continental Ancestry Group, Female, Healthcare Disparities, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Patient Discharge, Prospective Studies, Residence Characteristics, Sex Distribution, Stroke, United States
  • Digital Object Identifier (doi)

    Author List

  • Albright KC; Howard VJ; Howard G; Muntner P; Bittner V; Safford MM; Boehme AK; Rhodes JD; Beasley TM; Judd SE
  • Volume

  • 6
  • Issue

  • 8