Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature

Academic Article


  • Anaplastic oligodendroglioma (AO) is rare in children. Treatment typically consists of varying combinations of surgery, chemotherapy, and radiotherapy. We present a pediatric case of frontal lobe AO with periventricular subcallosal extension and local leptomeningeal involvement. The isocitrate dehydrogenase (IDH) wild-type tumor was MGMT methylated and contained an ATRX mutation, BRAF alteration, and 1p/19q co-deletion; a combination of alterations mostly encountered in pediatric oligodendrogliomas. The patient underwent a near total resection and had a complete, durable response to temozolomide alone, suggesting that conservative management without radiation may be appropriate in some cases. We review the literature of this uncommon subtype of glioma in children.
  • Digital Object Identifier (doi)

    Author List

  • Sorge C; Li R; Singh S; Reddy AT; Solomon DA; Perry A; Friedman GK
  • Volume

  • 64
  • Issue

  • 12