Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.

Academic Article

Abstract

  • Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells.
  • Authors

    Published In

  • Blood  Journal
  • Keywords

  • Animals, Apoptosis, Cell Differentiation, Cell Proliferation, Cells, Cultured, Forkhead Transcription Factors, Mice, Mice, Congenic, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Repressor Proteins, T-Lymphocytes, Thymus Gland, Transcription Factors
  • Digital Object Identifier (doi)

    Author List

  • Feng X; Ippolito GC; Tian L; Wiehagen K; Oh S; Sambandam A; Willen J; Bunte RM; Maika SD; Harriss JV
  • Start Page

  • 510
  • End Page

  • 518
  • Volume

  • 115
  • Issue

  • 3