Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein regulates the function of regulatory t cells

Academic Article

Abstract

  • Background: PARP-1 has importance in the immune system. Results: Poly(ADP-ribosyl)ation of FOXP3 mediated by PARP-1 destabilizes FOXP3 and negatively regulates the suppressive activity of Treg cells. Conclusion: PARP-1 negatively regulates Treg function via FOXP3 poly(ADP-ribosyl)ation. Significance: This study helps the development of PARP-1 inhibitors to prevent autoimmune diseases.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Luo X; Nie J; Wang S; Chen Z; Chen W; Li D; Hu H; Li B
  • Start Page

  • 28675
  • End Page

  • 28682
  • Volume

  • 290
  • Issue

  • 48