Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array.

Academic Article

Abstract

  • AIM: We conducted a genome-wide association study using the Illumina Exome Array to identify coding SNPs that may explain additional warfarin dose variability. PATIENTS & METHODS: Analysis was performed after adjustment for clinical variables and genetic factors known to influence warfarin dose among 1680 warfarin users (838 European-Americans and 842 African-Americans). Replication was performed in an independent sample. RESULTS: We confirmed the influence of known genetic variants on warfarin dose variability. Our study is the first to show the association between rs12772169 and warfarin dose in African-Americans. In addition, genes COX15 and FGF5 showed significant association in European-Americans. CONCLUSION: We identified some novel genes/SNPs that underpin warfarin dose response. Further replication is needed to confirm our findings.
  • Published In

  • Pharmacogenomics  Journal
  • Keywords

  • CYP2C9, CYP4F2, VKORC1, exome array, genome-wide association study, prediction models, warfarin, warfarin dose, African Americans, Anticoagulants, Cytochrome P-450 CYP2C9, Cytochrome P450 Family 4, European Continental Ancestry Group, Exome, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Pharmacogenomic Variants, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin
  • Digital Object Identifier (doi)

    Author List

  • Liu N; Irvin MR; Zhi D; Patki A; Beasley TM; Nickerson DA; Hill CE; Chen J; Kimmel SE; Limdi NA
  • Start Page

  • 1059
  • End Page

  • 1073
  • Volume

  • 18
  • Issue

  • 11