Effect of hydrocortisone and dexamethasone on xylose uptake by isolated rat soleus muscle

Academic Article

Abstract

  • To determine the effects of glucocorticoids on sugar uptake, xylose uptake by isolated rat soleus muscle of bilaterally adrenalectomized animals was studied. The results indicate that in vitro addition of 10-4 M hydrocortusine, dexamethasone or hydrocortisone sodium succinate had no inhibitory effect on basal xylose uptake. In the presence of both low and high medium insulin, the above steroids failed to inhibit insulin-stimulated uptake. When the concentration of hydrocortisone sodium succinate was increased to 10-2 M, insulin-stimulated uptake was decreased. The results thus indicate that glucocorticoids at concentrations observed under physiological or pathological conditions do not inihibit basal or insulin-stimulated sugar uptake. © 1975.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Chaudry IH; Scott Adzick N; Sayeed MM; Baue AE
  • Start Page

  • 85
  • End Page

  • 89
  • Volume

  • 399
  • Issue

  • 1