Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity

Academic Article

Abstract

  • Jejunal infusions of linoleic acid, corn oil, or caprylic acid significantly increased hepatic vagal afferent activity, whereas saline infusions were ineffective. The magnitude of response was greatest with either linoleic acid or corn oil. Hepatic portal infusions of linoleic acid, Liposyn II, or caprylic acid significantly increased hepatic vagal afferent activity, whereas 5% albumin/phosphate buffer vehicle was ineffective. The magnitude of response was greatest with either linoleic acid or Liposyn II. These data show that either jejunal or portal infusions of lipids increase activity of hepatic vagal afferents and could potentially serve as a complementary and/or alternative substrate to celiac vagal afferents in mediating the effects of jejunal infusions of lipids in suppressing food intake. © 2001 Lippincott Williams & Wilkins.
  • Authors

    Published In

  • NeuroReport  Journal
  • Digital Object Identifier (doi)

    Author List

  • Randich A; Spraggins DS; Cox JE; Meller ST; Kelm GR
  • Start Page

  • 3101
  • End Page

  • 3105
  • Volume

  • 12
  • Issue

  • 14