Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project.

Academic Article


  • PURPOSE: To codify the use of multiparametric magnetic resonance imaging (mpMRI) for the interrogation of prostate neoplasia (PCa) in clinical practice and focal therapy (FT). METHODS: An international collaborative consensus project was undertaken using the Delphi method among experts in the field of PCa. An online questionnaire was presented in three consecutive rounds and modified each round based on the comments provided by the experts. Subsequently, a face-to-face meeting was held to discuss and finalize the consensus results. RESULTS: mpMRI should be performed in patients with prior negative biopsies if clinical suspicion remains, but not instead of the PSA test, nor as a stand-alone diagnostic tool or mpMRI-targeted biopsies only. It is not recommended to use a 1.5 Tesla MRI scanner without an endorectal or pelvic phased-array coil. mpMRI should be performed following standard biopsy-based PCa diagnosis in both the planning and follow-up of FT. If a lesion is seen, MRI-TRUS fusion biopsies should be performed for FT planning. Systematic biopsies are still required for FT planning in biopsy-na├»ve patients and for patients with residual PCa after FT. Standard repeat biopsies should be taken during the follow-up of FT. The final decision to perform FT should be based on histopathology. However, these consensus statements may differ for expert centers versus non-expert centers. CONCLUSIONS: The mpMRI is an important tool for characterizing and targeting PCa in clinical practice and FT. Standardization of acquisition and reading should be the main priority to guarantee consistent mpMRI quality throughout the urological community.
  • Published In


  • Consensus, Delphi, Focal therapy, Magnetic resonance imaging, Prostate cancer, Ablation Techniques, Biopsy, Cryosurgery, Delphi Technique, Electrochemotherapy, High-Intensity Focused Ultrasound Ablation, Humans, Laser Therapy, Magnetic Resonance Imaging, Male, Pathologists, Photochemotherapy, Prostatic Neoplasms, Radiologists, Surveys and Questionnaires, Urologists
  • Digital Object Identifier (doi)

    Author List

  • Scheltema MJ; Tay KJ; Postema AW; de Bruin DM; Feller J; Futterer JJ; George AK; Gupta RT; Kahmann F; Kastner C
  • Start Page

  • 695
  • End Page

  • 701
  • Volume

  • 35
  • Issue

  • 5