© 2016 Elsevier Inc. All rights reserved. Objective To compare the outcomes of ureteroscopic intervention in terms of both the stone-free rate and complications in both prepubertal and adolescent patients. Although safety of pediatric ureteroscopic intervention is well established, a comparative outcome of prepubertal and adolescent patients is lacking. Materials and Methods Pediatric patients who underwent ureteroscopic treatment of a renal or ureteral stone at our institution from July 2005 to August 2014 were retrospectively identified. Patients were classified by age either as prepubertal (≤11 years) or adolescent (>11 years) for purposes of comparison. Demographic and intraoperative variables as well as 30-day postoperative complication rates were compared between groups. Data were analyzed using χ2 and Fisher's exact tests as appropriate. Results A total of 104 patients were identified, of whom 64 (62%) were prepubertal and 40 (38%) were adolescent. Ureteroscopic failure occurred in a minority of patients (5% vs 4.7%, P >.9). Complication rates including ureteral perforation (0% vs 1.6%, P >.9), postoperative urinary tract infection (2.5% vs 4.7%, P >.9), hematuria with clot passage (0% vs 7.8%, P =.15), and persistent flank pain (15% vs 17%, P =.85) were not significantly different between adolescent and prepubertal patients, respectively. Conclusion In spite of small size and small body habitus, the ureteroscopic management of pediatric urolithiasis can be performed successfully in both the prepubertal and adolescent patients with acceptable and equivalent morbidity as well as successful clearance of stone.