The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans.

Academic Article

Abstract

  • BACKGROUND: African Americans (AA) disproportionately develop lupus nephritis (LN) relative to European Americans and familial clustering supports causative genes. Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN. METHODS: Seven MYH9 single nucleotide polymorphisms (SNPs) and the E1 risk haplotype were tested for association with LN in three cohorts of AA. RESULTS: A preliminary analysis revealed that the MYH9 E1 risk haplotype was associated with ESRD in 25 cases with presumed systemic lupus erythematosus (SLE)-associated ESRD, compared to 735 non-SLE controls (odds ratio 3.1; p = 0.010 recessive). Replication analyses were performed in 583 AA with SLE in the PROFILE cohort (318 with LN; 265 with SLE but without nephropathy) and 60 AA from the NIH (39 with LN; 21 with SLE but without nephropathy). Analysis of the NIH and larger PROFILE cohorts, as well as a combined analysis, did not support this association. CONCLUSIONS: These results suggest that AA with ESRD and coincident SLE who were recruited from dialysis clinics more likely have kidney diseases in the MYH9-associated spectrum of focal segmental glomerulosclerosis. PROFILE and NIH participants, recruited from rheumatology practices, demonstrate that MYH9 does not contribute substantially to the development of LN in AA.
  • Published In

    Keywords

  • Adolescent, Adult, African Americans, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Lupus Nephritis, Male, Middle Aged, Molecular Motor Proteins, Myosin Heavy Chains, Polymorphism, Single Nucleotide, Risk Factors, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Freedman BI; Edberg JC; Comeau ME; Murea M; Bowden DW; Divers J; Alarc√≥n GS; Brown EE; McGwin G; Kopp JB
  • Start Page

  • 66
  • End Page

  • 72
  • Volume

  • 32
  • Issue

  • 1