Bone metabolism in oxalosis: A single-center study using new imaging techniques and biomarkers

Academic Article

Abstract

  • The deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria type 1 (PH1). We report here an evaluation of the bone status of 12 PH1 children based on bone biomarkers [parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23)] and radiological assessments (skeletal age, three-dimensional high-resolution peripheral quantitative computed tomography, HR-pQCT) carried out within the framework of a cross-sectional single-center study. The controls consisted of healthy and children with chronic kidney disease already enrolled in local bone and mineral metabolism studies. The mean age (±standard deviation) age of the patients was 99 (±63) months. Six children suffered from fracture. Bone maturation was accelerated in five patients, four of whom were <5 years. The combination of new imaging techniques and biomarkers highlighted new and unexplained features of PH1: advanced skeletal age in young PH1 patients, increased FGF23 levels and decreased total volumetric bone mineral density with bone microarchitecture alteration. © 2010 IPNA.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Bacchetta J; Fargue S; Boutroy S; Basmaison O; Vilayphiou N; Plotton I; Guebre-Egziabher F; Dohin B; Kohler R; Cochat P
  • Start Page

  • 1081
  • End Page

  • 1089
  • Volume

  • 25
  • Issue

  • 6