Successful treatment with IVIg therapy of diabetes-associated scleredema severe progressive case and review of the literature.

Academic Article


  • Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans ("mucins"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chronic and treatment options are limited. We report a case of a patient diagnosed with scleredema associated with longstanding insulin dependent diabetes who was treated successfully with IVIg. Additionally, we have reviewed the literature reporting other patients with scleredema treated with IVIg.
  • Published In


  • IVIg, intravenous immunoglobulin, scleredema, therapy, treatment, Adult, Dermatologic Agents, Diabetes Complications, Diabetes Mellitus, Type 1, Disease Progression, Female, Humans, Immunoglobulins, Intravenous, Scleredema Adultorum
  • Digital Object Identifier (doi)

    Author List

  • Kennemer C; Pavlidakey P; Sami N
  • Volume

  • 30
  • Issue

  • 4