African-American and Hispanic ethnicities, renal involvement and obesity predispose to hypertension in systemic lupus erythematosus: results from LUMINA, a multiethnic cohort (LUMINAXLV).

Academic Article

Abstract

  • OBJECTIVE: To examine the predictors of the occurrence of hypertension in a large multiethnic US cohort. PATIENTS AND METHODS: There were 614 patients with systemic lupus erythematoses (SLE; > or = 4 American College of Rheumatology revised criteria) with < or = 5 years of disease duration at entry into the cohort (T0) and of Hispanic (Texan or Puerto Rican), African-American or Caucasian ethnicity. T0 variables were compared between patients who did and did not develop hypertension (blood pressure > or = 140/90 mm Hg on at least two occasions and/or the use of antihypertensive drugs) after T0. Significant and clinically relevant variables were then examined by a stepwise logistic regression model. RESULTS: A total of 379 patients without hypertension at T0 were included (patients who developed hypertension prior to SLE diagnosis (n = 126) or before T0 (n = 109) were excluded). Predictors of hypertension were African-American and Texan-Hispanic ethnicities, renal involvement and a higher body mass index. CONCLUSIONS: Traditional cardiovascular risk factors, disease-related factors and ethnicity play a role in the occurrence of hypertension in patients with SLE. Controlling renal involvement and optimising body weight may prevent the occurrence of hypertension.
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    Keywords

  • Adult, African Americans, Antibodies, Antinuclear, Antibodies, Antiphospholipid, Cholesterol, LDL, Cohort Studies, DNA, Female, Hispanic Americans, Humans, Hypertension, Kidney Diseases, Lupus Erythematosus, Systemic, Male, Obesity, Risk Factors, United States
  • Digital Object Identifier (doi)

    Author List

  • Chaiamnuay S; Bertoli AM; Roseman JM; McGwin G; Apte M; Durán S; Vilá LM; Reveille JD; Alarcón GS
  • Start Page

  • 618
  • End Page

  • 622
  • Volume

  • 66
  • Issue

  • 5