An official American Thoracic Society Workshop Report: Chemical inhalational disasters biology of lung injury, development of novel therapeutics, and medical preparedness

Academic Article

Abstract

  • © 2017 by the American Thoracic Society. This report is based on the proceedings from the Inhalational Lung InjuryWorkshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental,Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectiveswere to (1) provide a forumto review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 23740976
  • Author List

  • Summerhill EM; Hoyle GW; Jordt SE; Jugg BJ; Martin JG; Matalon S; Patterson SE; Prezant DJ; Sciuto AM; Svendsen ER
  • Start Page

  • 1060
  • End Page

  • 1072
  • Volume

  • 14
  • Issue

  • 6