Vitreal penetration of oral moxifloxacin in humans.

Academic Article

Abstract

  • PURPOSE: To investigate the vitreal penetration of moxifloxacin after oral administration. DESIGN: Prospective, nonrandomized clinical series. METHODS: Twenty-four patients (mean age = 62.8 years) undergoing elective pars plana vitrectomy were assigned to a dosing group: control (n = 3), which received no medication; single-dose (n = 11), which received one 400 mg oral dose of moxifloxacin 3 hours before surgery; and five-dose (n = 10), which received one 400 mg dose on each of the 4 days preceding surgery and a fifth dose 3 hours before surgery. Vitreous samples were obtained and analyzed. RESULTS: Control, below quantifiable levels; single-dose, 0.572 +/- 0.239 microg/mL; and five-dose, 1.200 +/- 0.645 microg/mL. CONCLUSIONS: Five doses of oral moxifloxacin lead to higher intravitreal drug concentrations than single-dose administration. Both regimens, however, achieve levels that exceed the MIC90 of many bacteria implicated in postoperative endophthalmitis.
  • Authors

    Published In

  • RETINA  Journal
  • Keywords

  • Administration, Oral, Adult, Aged, Aged, 80 and over, Anti-Infective Agents, Antibiotic Prophylaxis, Aza Compounds, Endophthalmitis, Fluoroquinolones, Humans, Middle Aged, Moxifloxacin, Prospective Studies, Quinolines, Vitrectomy, Vitreous Body
  • Digital Object Identifier (doi)

    Author List

  • Lott MN; Fuller JJ; Hancock HA; Singh J; Singh H; McGwin G; Marcus DM
  • Start Page

  • 473
  • End Page

  • 476
  • Volume

  • 28
  • Issue

  • 3