Alternative interventional study designs

Chapter

Abstract

  • There are many variations to the classical randomized controlled trial. These variations are utilized when, for a variety of reasons, the classical randomized controlled trial would be impossible, inappropriate, or impractical. Some of the variations are described in this chapter and include: equivalence and noninferiority trials; crossover trials; N of 1 trials, case-crossover trials, and externally controlled trials. Large simple trials, and prospective randomized, open-label, blinded endpoint trials are discussed in another chapter. © Springer Science + Business Media B.V. 2008.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9781402084850
  • Start Page

  • 63
  • End Page

  • 71