Is there an association between the prevalence of atrial fibrillation and severity and control of hypertension? The REasons for Geographic And Racial Differences in Stroke study.

Academic Article


  • The association of atrial fibrillation (AF) with the severity and control of hypertension (HTN) remains unclear. We analyzed data from the national biracial cohort of REasons for Geographic And Racial Differences in Stroke study. The AF prevalence ratios were estimated and full multivariable adjustment included demographics, risk factors, medication adherence, HTN duration, and antihypertensive medication classes. Of the 30,018 study participants (8.6% with AF), 4386 had normotension (4.3% with AF), 5916 had prehypertension (4.3 with AF%), 12,294 had controlled HTN (11.2% with AF), 5587 had uncontrolled HTN (8.1% with AF), 547 had controlled apparent treatment-resistant hypertension (aTRH) (19.2% with AF), and 1288 had uncontrolled aTRH (15.5% with AF). Compared with normotension, the AF prevalence ratios for prehypertension, controlled HTN, uncontrolled HTN, controlled aTRH, and uncontrolled aTRH groups in fully adjusted model were 1.01 (95% confidence interval: 0.84, 1.21), 1.42 (1.18, 1.71), 1.37 (1.14, 1.65), 1.17 (0.86, 1.58), and 1.42 (1.10, 1.84), respectively (P < .001). The prevalence of AF was similar among persons with HTN regardless of blood pressure level and antihypertensive treatment resistance.
  • Keywords

  • Antihypertensive medications, beta-blockers, blood pressure, treatment-resistant hypertension, African Continental Ancestry Group, Age Factors, Aged, Antihypertensive Agents, Atrial Fibrillation, Blood Pressure Determination, Cohort Studies, Cross-Sectional Studies, European Continental Ancestry Group, Female, Humans, Hypertension, Male, Middle Aged, Prehypertension, Prevalence, Risk Factors, Severity of Illness Index, Sex Factors
  • Digital Object Identifier (doi)

    Author List

  • Bhatt H; Gamboa CM; Safford MM; Soliman EZ; Glasser SP
  • Start Page

  • 578
  • End Page

  • 586.e5
  • Volume

  • 10
  • Issue

  • 7