Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22-21.3

Academic Article

Abstract

  • A novel ARNSHI (autosomal recessive non-syndromic hearing impairment) locus, DFNB71, was localized to 8p22-21.3. To map the locus, a whole-genome scan was carried out using DNA samples from a consanguineous seven-generational Pakistani family with profound prelingual ARNSHI. A maximum multipoint LOD score of 4.2 occurred at marker D8S261. The DFNB71 region of homozygosity and 3-unit support interval is flanked by markers D8S1130 and D8S1786. This region has a genetic distance of 19.1 cM and contains 10.6 Mb of sequence. © 2009 The Japan Society of Human Genetics All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Chishti MS; Lee K; McDonald ML; Hassan MJ; Ansar M; Ahmad W; Leal SM
  • Start Page

  • 141
  • End Page

  • 144
  • Volume

  • 54
  • Issue

  • 3