Design, synthesis, and biological action of 20 R -hydroxyvitamin D3

Academic Article


  • The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated by semipreparative HPLC, and its structure is characterized. A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies. © 2012 American Chemical Society.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Lu Y; Chen J; Janjetovic Z; Michaels P; Tang EKY; Wang J; Tuckey RC; Slominski AT; Li W; Miller DD
  • Start Page

  • 3573
  • End Page

  • 3577
  • Volume

  • 55
  • Issue

  • 7